E. coli and Salmonella Workshop 7th June 2007, Utrecht, NL

The sequencing of the genomes of several bacterial species, including pathogens, opened the post-genomic era of medical bacteriology. Today we can compare not only the genomes of different pathogenic and non-pathogenic strains of the same bacterial species, but also the expression of putative virulence genes in different growth conditions, in a cellular growth media or in contact with eucaryotic cell in culture, using microarrays. The contribution of microbial genomics to the understanding of bacterium-host inter-relationships was the main theme of this workshop, which took Salmonella enterica and enterohaemorrhagic Escherichia coli (EHEC) as examples of the power of these new tools.

Programme

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Postgenomics in enterohaemorrhagic Escherichia coli and Salmonella enterica

• Welcome and Introduction: Enterohaemorrhagic E. coli and Salmonella - Jacques Mainil, Belgium

Session 1:  The bacteria (Chair:  Y. Wasteson, Norway)

• Genomics of different enterohaemorrhagic E. coli serotypes - Tetsuya Hayashi, Japan
• Genes of Salmonella enterica required for enteric and systemic virulence - Mark Stevens, UK
• Application of suppressive subtractive hybridization to identify host-specific virulence factors of enterohaemorrhagic Escherichia coli strains of serogroup O26 - Marjorie Bardiau, Belgium
• Optimised sample sizes for analysing the genetic heterogeneity of non type specific Escherichia coli including verotoxigenic E. coli from ovine and bovine faeces - Dorte Döpfer, The Netherlands
• Virulotyping of new and emerging Salmonella and verotoxigenic E. coli - Roberto La Ragione, UK
• Molecular epidemiology of salmonella genomic island 1 (SGI1) - Dik J. Mevius, The Netherlands